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ECVAMes_Positives List: ECVAM Ames Positives List: EURL ECVAM Genotoxicity and Carcinogenicity Database of Ames Positive Chemicals This list of 726 chemicals derives from the EURL ECVAM database of curated in vitro and in vivo genotoxicity and carcinogenicity data for Ames positive chemicals, that was compiled from a variety of sources: EU and international regulatory agencies, industry and scientific literature databases. The database is intended to aid in the development and evaluation of alternative approaches to animal testing. It has already been used to evaluate the predictivity of the in vitro Ames test for in vivo genotoxicity and carcinogenicity when used alone or in combination with in vitro assays based on mammalian cells, and for a better characterisation of those cases where the Ames test leads to misleading ('false positive') results (Kirkland et al., Mutation Research, Volumes 775.776, Pages 69.80, 2014). 1 2 3 4 (723 chemicals) download  excel file 
CASEINECSChemical NameSMILES
100-17-4 202-825-3p-NitroanisoleCOc1ccc(cc1)[N+](=O)[O-]
100-63-0 202-873-5Phenylhydrazine (free base)NNc1ccccc1
100-75-4 202-886-6N-NitrosopiperidineO=NN1CCCCC1
10028-15-6 233-069-2Ozone[O-][O+]=O
101-80-4 202-977-04,4'-OxydianilineNc1ccc(Oc2ccc(N)cc2)cc1
10102-44-0 233-272-6Nitrogen dioxide[N](=O)=O
10595-95-6 NitrosoethylmethylamineCCN(C)N=O
106-50-3 203-404-7p- Phenylenediamine (COLIPA: A7) (free base)Nc1ccc(N)cc1
108-45-2 203-584-7m-PhenylenediamineNc1cccc(N)c1
1116-54-7 214-237-4N-NitrosodiethanolamineOCCN(CCO)N=O
122-60-1 204-557-2Phenylglycidyl etherC(Oc1ccccc1)C2CO2
125-33-7 204-737-0Primaclone (primidone)CCC1(C(=O)NCNC1=O)c2ccccc2
126-85-2 Nitrogen mustard N-oxideN(CCCl)(CCCl)(C)=O
13024-49-2 4-(2-Phenylethyl)anilineC1=CC=C(C=C1)CCC2=CC=C(C=C2)N
13171-21-6 236-116-5PhosphamidonCCN(CC)C(=O)\C(=C(/C)\OP(=O)(OC)OC)\Cl
13366-73-9 PhotodieldrinClC6C2(Cl)C4(Cl)C(Cl)(Cl)C6(Cl)C5C3C1OC1C(C23)C45
144644-13-3 PEG-3-2',2'-di-p-phenylelenediamine COLIPA A146
14698-29-4 238-750-8Oxolinic acidCCN1C=C(C(=O)O)C(=O)c2cc3OCOc3cc12
156-10-5 205-848-7p-NitrosodiphenylamineO=Nc1ccc(Nc2ccccc2)cc1
156-51-4 205-856-0Phenylethylhydrazine sulphatec1ccc(cc1)CCNN.OS(=O)(=O)O
16219-98-0 2-NitrosomethylaminopyridineCN(C1=CC=CC=N1)N=O
16543-55-8 N-NitrosonornicotineC1CC(N(C1)N=O)C2=CN=CC=C2
16813-36-8 1-Nitroso-5,6-dihydrouracilO=C1NC(=O)N(N=O)CC1
17117-34-9 3-NitrobenzanthroneC1=CC=C2C(=C1)C3=C4C(=C(C=C3)[N+](=O)[O-])C=CC=C4C2=O
1825-21-4 PentachloroanisoleClc1c(OC)c(Cl)c(Cl)c(Cl)c1Cl
1836-75-5 217-406-0Nitrofen[O-][N+](=O)c1ccc(Oc2ccc(Cl)cc2Cl)cc1
1955-45-9 PivalolactoneO=C1OCC1(C)C
20917-49-1 NitrosoheptamethyleneimineO=NN1CCCCCCC1
2243-78-9 2-nitrobenzidinec1cc(ccc1c2ccc(cc2[N+](=O)[O-])N)N
2278-22-0 218-905-6Peroxyacetyl nitrateCC(=O)OO[N+](=O)[O-]
230-46-6 1,7-PhenanthrolineC1=CC2=C(C3=C(C=C2)N=CC=C3)N=C1
23696-28-8 245-832-7OlaquindoxCc1c(n(=O)c2ccccc2n1=O)C(=O)NCCO
24554-26-5 N-[4-(5-Nitro-2-furyl)-2-thiazolyl]formamideC1=C(OC(=C1)[N+](=O)[O-])C2=CSC(=N2)NC=O
2578-75-8 N-[5-(5-Nitro-2-furyl)-1,3,4-thiadazol-2-yl]acetamideCC(=O)NC1=NN=C(S1)C2=CC=C(O2)[N+](=O)[O-]
2608-48-2 5-(4-Nitrophenyl)-2,4-pentadien-1-al (AKA Spy dust)O=[N+]([O-])c1ccc(\C=C\C=C\C=O)cc1
2646-17-5 220-162-8Oil orange SSCc1ccccc1N=Nc2c(O)ccc3ccccc23
26541-51-5 N-NitrosothiomorpholineC1CSCCN1N=O
27080-42-8 4-Nitrophenyl aminothyourea - COLIPA B70[O-][N+](=O)c1ccc(NCCNC(=O)N)cc1
298-00-0 206-050-1Parathion-methylCOP(=S)(OC)Oc1ccc(cc1)[N+](=O)[O-]
301-12-2 206-110-7Oxydemeton-methylCCS(=O)CCSP(=O)(OC)OC
36133-88-7 "N-{[3-(5-Nitro-2-furyl)-1,2,4-oxadiazole 5-yl]-methyl}acetamide"CC(=O)NCC1=NC(=NO1)C2=CC=C(O2)[N+](=O)[O-]
38777-13-8 Nitroso-BaygonO=NN(C(=O)Oc1ccccc1OC(C)C)C
4003-94-5 223-653-54-Nitrostilbene[O-][N+](=O)c1ccc(\C=C\c2ccccc2)cc1
40580-89-0 NitrosododecamethyleneimineC1CCCCCCN(CCCCC1)N=O
42579-28-2 1-NitrosohydantoinO=C1NC(=O)N(N=O)C1
50-06-6 200-007-0PhenobarbitalCCC1(C(=O)NC(=O)NC1(=O))c2ccccc2
504-88-1 208-003-03-Nitroproprionic acidOC(=O)CC[N+](=O)[O-]
51-71-8 200-117-9PhenelzineNNCCc1ccccc1
51-75-2 200-120-5Nitrogen mustard - ChlormethineCN(CCCl)CCCl
51-98-9 200-132-0Norethisterone acetateCC(=O)O[C@]1(CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@]12C)C#C
51325-35-0 "N,N'-[6-(5-Nitro-2-furyl)-s-triazine-2,4-diyl] bisacetamide"CC(=O)NC1=NC(=NC(=N1)C2=CC=C(O2)[N+](=O)[O-])NC(=O)C
5255-75-4 226-057-34-Nitrophenyl glycidyl ether[O-][N+](=O)c1ccc(OCC2CO2)cc1
5307-14-2 226-164-52-Nitro-p-phenylenediaminec1cc(c(cc1N)[N+](=O)[O-])N
531-82-8 N-[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamide (Furazolidone)CC(=O)NC1=NC(=CS1)C2=CC=C(O2)[N+](=O)[O-]
5336-53-8 N-NitrosodibenzylamineC1=CC=C(C=C1)CN(CC2=CC=CC=C2)N=O
53757-28-1 4-(5-Nitro-2-furyl)thiazole[O-][N+](=O)c2oc(c1ncsc1)cc2
53910-25-1 PentostatinO[C@@H]3CNC=Nc2c3ncn2[C@H]1C[C@H](O)[C@@H](CO)O1
55-18-5 200-226-1N-Nitrosodiethylamine (diethylnitrosamine)CCN(CC)N=O
5522-43-0 226-868-21-Nitropyrene[O-][N+](=O)c1ccc2ccc3cccc4ccc1c2c34
55556-92-8 Nitroso-1,2,3,6-tetrahydropyridineC1CN(CC=C1)N=O
56-57-5 200-281-14-Nitroquinoline-N-oxidec12c(n(=O)ccc1[N+](=O)[O-])cccc2
56222-35-6 N-Nitroso-3-hydroxypyrrolidineO=NN1CCC(O)C1
5632-47-3 N-NitrosopiperazineO=NN1CCNCC1
570-24-1 209-329-66-Nitro-o-toloudine COLIPA B56Cc1cccc(c1N)[N+](=O)[O-]
581-89-5 209-474-52-Nitronaphthalene[O-][N+](=O)c1ccc2ccccc2c1
59-87-0 200-443-15-Nitro-2-furaldehyde semicarbazone (AKA Nitrofurazone)NC(=O)N\N=C\c1oc(cc1)[N+](=O)[O-]
59-89-2 N-NitrosomorpholineO=NN1CCOCC1
59-96-1 200-446-8Phenoxybenzamine (free base)CC(COc1ccccc1)N(CCCl)Cc2ccccc2
607-35-2 210-135-98-Nitroquinoline[O-][N+](=O)c1cccc2cccnc12
607-57-8 210-138-52-Nitrofluorenec12c3c(cccc3)Cc1cc([N+](=O)[O-])cc2
614-95-9 NitrosoethylurethanO=C(OCC)N(N=O)CC
61841-39-2 3-nitrobenzidineO=[N+]([O-])c1cc(ccc1N)c2ccc(N)cc2
62-23-7 200-526-2p-Nitrobenzoic acidc1cc(ccc1C(=O)O)[N+](=O)[O-]
62-44-2 200-533-0PhenacetinCCOc1ccc(NC(=O)C)cc1
62-75-9 200-549-8N-Nitrosodimethylamine (dimethylnitrosamine)CN(C)N=O
621-64-7 210-698-0N-Nitrosodipropylamine [dipropylnitrosamine]CCCN(CCC)N=O
64091-91-4 NNKc1(C(CCCN(N=O)C)=O)cccnc1
67-20-9 200-646-5"1-[(5-Nitrofurfurylidene)amino]hydantoin (AKA Nitrofurantoin)"c1cc(oc1/C=N/N2CC(=O)NC2=O)[N+](=O)[O-]
684-93-5 211-678-4N-Nitroso-N-methylureaCN(N=O)C(=O)N
7227-91-0 230-627-71-Phenyl-3,3-dimethyltriazeneCN(C)N=Nc1ccccc1
732-11-6 211-987-4PhosmetCOP(=S)(OC)SCN1C(=O)c2ccccc2C1=O
7496-02-8 6-NitrochryseneC1=CC=C2C(=C1)C=CC3=C2C=C(C4=CC=CC=C34)[N+](=O)[O-]
79-46-9 201-209-12-NitropropaneCC(C)[N+](=O)[O-]
80-51-3 201-286-14,4'-Oxybis(Benzenesulfonylhydrazide)NNS(=O)(=O)c1ccc(Oc2ccc(cc2)S(=O)(=O)NN)cc1
86-57-7 201-684-51-Nitronaphthalene[O-][N+](=O)c1cccc2ccccc12
88-89-1 201-865-9Picric acidOc1c(cc(cc1[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-]
89911-79-5 N-Nitroso-2,3-dihydroxypropyl-2-hydroxypropyl-amineO=NN(CC(O)C)CC(O)CO
90-43-7 201-993-5o-Phenylphenol (2-phenylphenol)Oc1ccccc1-c2ccccc2
91-23-6 202-052-1o-NitroanisoleCOc1ccccc1[N+](=O)[O-]
92-93-3 202-204-74-nitrobiphenyl[O-][N+](=O)c1ccc(cc1)c2ccccc2
924-16-3 213-101-1NitrosodibutylamineCCCCN(CCCC)N=O
930-55-2 213-218-8N-Nitrosopyrrolidine / mesH: 35844-45-8O=NN1CCCC1
932-83-2 213-258-6N-NitrosohexamethyleneimineO=NN1CCCCCC1
937-40-6 N-NitrosomethylbenzylamineCN(CC1=CC=CC=C1)N=O
94-52-0 202-341-26-nitrobenzimidazolec1cc2c(cc1[N+](=O)[O-])nc[nH]2
94-78-0 202-363-2Phenazopyridine (free base)Nc1ccc(N=Nc2ccccc2)c(N)n1
95-54-5 202-430-6o-Phenylenediamine (free base)Nc1ccccc1N
96-91-3 202-544-6Picramic acidNc1cc(cc(c1O)[N+](=O)[O-])[N+](=O)[O-]
99-55-8 202-765-85-Nitro-o-toluidineCc1ccc(cc1N)[N+](=O)[O-]
99-56-9 202-766-34-Nitro-o-phenylenediamine (free base)Nc1ccc(cc1N)[N]([O])=O |^1:8,9|
99-59-2 202-770-55-Nitro-o-anisidineCOc1ccc(cc1N)[N+](=O)[O-]
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