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ECVAMes_Positives List: ECVAM Ames Positives List: EURL ECVAM Genotoxicity and Carcinogenicity Database of Ames Positive Chemicals This list of 726 chemicals derives from the EURL ECVAM database of curated in vitro and in vivo genotoxicity and carcinogenicity data for Ames positive chemicals, that was compiled from a variety of sources: EU and international regulatory agencies, industry and scientific literature databases. The database is intended to aid in the development and evaluation of alternative approaches to animal testing. It has already been used to evaluate the predictivity of the in vitro Ames test for in vivo genotoxicity and carcinogenicity when used alone or in combination with in vitro assays based on mammalian cells, and for a better characterisation of those cases where the Ames test leads to misleading ('false positive') results (Kirkland et al., Mutation Research, Volumes 775.776, Pages 69.80, 2014). 1 2 3 4 (723 chemicals) download  excel file 
CASEINECSChemical NameSMILES
29539-03-5 Dihydroxyindoline HBr COLIPA A147Br.Oc1cc2CCNc2cc1O
29611-03-8 249-727-7AflatoxicolCOc1cc2O[C@@H]3OC=C[C@H]3c2c4OC(=O)C5=C(CC[C@H]5O)c14
299-75-2 206-081-0TreosulfanCS(=O)(=O)OCC(O)C(O)COS(=O)(=O)C
300-62-9 206-096-2AmphetamineCC(N)CC1=CC=CC=C1
301-12-2 206-110-7Oxydemeton-methylCCS(=O)CCSP(=O)(OC)OC
302-01-2 206-114-9HydrazineNN
302-17-0 206-117-5Chloral hydrateOC(O)C(Cl)(Cl)Cl
305-03-3 206-162-0ChlorambucilOC(=O)CCCc1ccc(cc1)N(CCCl)CCCl
30516-87-1 3'-Azido-3'-deoxythymidine (Zidovudine, AZT) and GSK33Cc1cn(c(=O)[nH]c1=O)[C@H]2C[C@@H]([C@H](O2)CO)N=[N+]=[N-]
306-37-6 206-183-51,2-Dimethylhydrazine 2HClN(NC)C.Cl.Cl
3068-88-0 221-330-3Beta-butyrolactoneCC1CC(=O)O1
3105-97-3 221-463-7HycanthoneCCN(CC)CCNc1ccc(CO)c2Sc3ccccc3C(=O)c12
313-67-7 206-238-3Aristolochic acidCOc1cccc2c1cc([N]([O])=O)c3c(cc4OCOc4c23)C(O)=O |^1:10,11|
3179-89-3 221-665-5Disperse red 17/ Cl 11210 COLIPA B5Cc1cc(ccc1N=Nc2ccc(cc2)[N+](=O)[O-])N(CCO)CCO
32362-68-8 6,11-Dimethylbenzo(b)naphthol(2,3-d)thiophenes2c1ccccc1c3c2c(c4c(c3C)cccc4)C
3252-43-5 221-843-2DibromoacetonitrileBrC(Br)C#N
3296-90-0 221-967-72,2-Bis(Bromomethyl)-1,3-propanediol, technical gradeOCC(CO)(CBr)CBr
33229-34-4 251-410-3HC Blue 2 - COLIPA B037OCCNc1ccc(cc1[N+](=O)[O-])N(CCO)CCO
3365-85-3 4,4''-Diaminoterphenyl C1=CC(=CC=C1C2=CC=C(C=C2)N)C3=CC=C(C=C3)N
33868-17-6 MethylnitrosocyanamideN#CN(N=O)C
34237-98-4 3-3'-DibromobenzidineBrc2cc(c1ccc(N)c(Br)c1)ccc2N
34256-82-1 251-899-3AcetochlorCCOCN(C(=O)CCl)c1c(C)cccc1CC
34911-55-2 BupropionCC(C(=O)c1cccc(c1)Cl)NC(C)(C)C
3544-23-8 3-Methoxy-4-aminoazobenzeneCOC1=C(C=CC(=C1)/N=N/C2=CC=CC=C2)N
36133-88-7 "N-{[3-(5-Nitro-2-furyl)-1,2,4-oxadiazole 5-yl]-methyl}acetamide"CC(=O)NCC1=NC(=NO1)C2=CC=C(O2)[N+](=O)[O-]
366-70-1 206-678-6Procarbazine (HCl)c1(C(NC(C)C)=O)ccc(CNNC)cc1.Cl
36711-31-6 Bis(2,3-dibromopropyl)phosphate, magnesium saltC(C(CBr)Br)OP(=O)(O)OCC(CBr)Br.[Mg]
3761-53-3 223-178-3C.I. Acid red 26 (AKA D&C Red 5 and Ponceau MX)Cc1ccc(c(c1)C)/N=N/c2c3ccc(cc3cc(c2O)S(=O)(=O)[O-])S(=O)(=O)[O-].[Na+].[Na+]
3778-73-2 223-237-3IsophosphamideClCCNP1(=O)OCCCN1CCCl
38434-77-4 EthylnitrosocyanamideN#CN(N=O)CC
38514-71-5 2-Amino-4-(5-nitro-2-furyl)thiazoleC1=C(OC(=C1)[N+](=O)[O-])C2=CSC(=N2)N
532-27-4 208-531-1ChloroacetophoneClCC(=O)c1ccccc1
536-90-3 208-651-4m-Anisidine (3-methoxybenzeneamine)COc1cccc(N)c1
54-05-7 200-191-2ChloroquineCCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12
54-85-3 200-214-6IsoniazidNNC(=O)c1ccncc1
540-23-8 208-740-8p-Toluidine HCl[Cl-].Cc1ccc([NH3+])cc1
540-51-2 208-748-12-BromoethanolOCCBr
54381-16-7 259-134-5N,N-Bis(2-hydroxyethyl)-p-phenylenediamine sulfate COLIPA A50Nc1ccc(cc1)N(CCO)CCO.S(=O)(=O)(O)O
55-18-5 200-226-1N-Nitrosodiethylamine (diethylnitrosamine)CCN(CC)N=O
55-38-9 200-231-9FenthionCOP(=S)(OC)Oc1ccc(SC)c(C)c1
55-63-0 200-240-8Trinitroglycerin[O-][N+](=O)OCC(CO[N+](=O)[O-])O[N+](=O)[O-]
55-80-1 200-243-43'-Methyl-4-dimethylaminoazobenzeneCN(C)c1ccc(cc1)N=Nc2cccc(C)c2
55-98-1 200-250-2Busulfan -compound GSK 34C[S](=O)(=O)OCCCCO[S](C)(=O)=O
55556-92-8 Nitroso-1,2,3,6-tetrahydropyridineC1CN(CC=C1)N=O
55557-00-1 DinitrosohomopiperazineC1CN(CCN(C1)N=O)N=O
556-52-5 209-128-3GlycidolOCC1CO1
56-49-5 200-276-43-MethylcholanthreneCc1ccc2cc3c(ccc4ccccc34)c5CCc1c25
56-55-3 200-280-6Benz[a]anthracene c1ccc2cc3c(ccc4ccccc34)cc2c1
56-57-5 200-281-14-Nitroquinoline-N-oxidec12c(n(=O)ccc1[N+](=O)[O-])cccc2
56654-52-5 1,3-Dibutyl-1-nitrosoureaO=C(N(N=O)CCCC)NCCCC
581-89-5 209-474-52-Nitronaphthalene[O-][N+](=O)c1ccc2ccccc2c1
58139-48-3 4-Morpholino-2-(5-nitro-2-thienyl)quinazolineC1COCCN1C2=NC(=NC3=CC=CC=C32)C4=CC=C(S4)[N+](=O)[O-]
59-87-0 200-443-15-Nitro-2-furaldehyde semicarbazone (AKA Nitrofurazone)NC(=O)N\N=C\c1oc(cc1)[N+](=O)[O-]
59-89-2 N-NitrosomorpholineO=NN1CCOCC1
59-96-1 200-446-8Phenoxybenzamine (free base)CC(COc1ccccc1)N(CCCl)Cc2ccccc2
591-27-5 209-711-23-Aminophenolc1cc(cc(c1)O)N
65701-06-6 265-882-34,4'-Methylenediamine (free base)[O-]C(=O)c1ccc(cc1C(=O)OCC)C(=O)c2cc(C(=O)OCC)c(C([O-])=O)cc2.c1(ccc(cc1)[NH3+])Cc2ccc(cc2)[NH3+]
66-27-3 200-625-0Methyl methanesulphonateCOS(=O)(=O)C
66-75-1 200-631-3Uracil mustardClCCN(CCCl)C1=CNC(=O)NC1=O
66095-81-6 266-138-02-Hydroxyethylamino-5-nitroanisole - COLIPA B52COc1cc(ccc1NCCO)[N+](=O)[O-]
66422-95-5 266-357-12,4-Diaminophenoxyethanol HCl - COLIPA A42c1(c(cc(N)cc1)N)OCCO.Cl.Cl
67-20-9 200-646-5"1-[(5-Nitrofurfurylidene)amino]hydantoin (AKA Nitrofurantoin)"c1cc(oc1/C=N/N2CC(=O)NC2=O)[N+](=O)[O-]
67730-10-3 2-Aminodipyrido[1,2-a:3',2'-d]imidazole (Glu-P-2)n3c1c(nc2ccccn12)ccc3N
67730-11-4 2-Amino-6-methyldipyridol[1,2-a:3',2'-d]imidazole (Glu-P-1)n3c1c(nc2c(cccn12)C)ccc3N
68-76-8 200-692-6Triaziquone (Trenimon)O=C1C=C(N2CC2)C(=O)C(=C1N3CC3)N4CC4
680-31-9 211-653-8HexamethylphosphoramideCN(C)P(=O)(N(C)C)N(C)C
68006-83-7 Mea-alpha-C (free base)n2c(c(cc3c1c(cccc1)nc23)C)N
683-18-1 211-670-0Dibuthyltin dichlorideCCCC[Sn](Cl)(Cl)CCCC
68391-32-2 269-944-0Basic brown 17/CI 12251 COLIPA B7[N+](c1cc(\N=N\c2c3cc([N+](C)(C)C)ccc3ccc2O)ccc1N)([O-])=O.[ClH-]
684-93-5 211-678-4N-Nitroso-N-methylureaCN(N=O)C(=O)N
68808-54-8 "3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole acetate (Trp-P-1 acetate)"O=C(O)C.n3c(c2c1c(cccc1)nc2c(c3N)C)C
68884-32-2 1-Naphthylpropylene oxideO3C(Cc1cccc2c1cccc2)C3
69-72-7 200-712-3Salicylic Acid OC(=O)c1ccccc1O
6923-22-4 230-042-7MonocrotophosCNC(=O)\C=C(/C)\OP(=O)(OC)OC
6959-47-3 230-149-92-(Chloromethyl)pyridine hydrochloridec1ccnc(c1)CCl.Cl
6959-48-4 230-150-43-(Chloromethyl)pyridine HClc1cc(cnc1)CCl.Cl
79-43-6 201-207-0Dichloroacetic acidOC(=O)C(Cl)Cl
79-44-7 201-208-6Dimethylcarbamoyl chlorideCN(C)C(=O)Cl
79-46-9 201-209-12-NitropropaneCC(C)[N+](=O)[O-]
80-51-3 201-286-14,4'-Oxybis(Benzenesulfonylhydrazide)NNS(=O)(=O)c1ccc(Oc2ccc(cc2)S(=O)(=O)NN)cc1
80-62-6 201-297-1Methyl methacrylateCOC(=O)C(=C)C
8001-35-2 232-283-3ToxapheneClCC1(CCl)C(=C)C2(Cl)C(Cl)C(Cl)C1(Cl)C2(Cl)Cl
8003-22-3 232-318-2D&C Yellow 11 (AKA C.I. Solvent Yellow 33)O=C1C(C(=O)c2ccccc12)c3ccc4ccccc4n3
8007-45-2 232-361-7Coal tar
81-49-2 201-354-01-Amino-2,4-dibromoanthraquinoneNc1c(Br)cc(Br)c2C(=O)c3ccccc3C(=O)c12
81-55-0 201-360-3ChrysazinOc1ccc(c2C(=O)c3c(C(=O)c12)c(O)ccc3[N+](=O)[O-])[N+](=O)[O-]
816-57-9 N-Propyl-N-nitrosoureaO=C(N)N(N=O)CCC
81612-54-6 HC Orange 3 - COLIPA B68c1cc(c(cc1OCC(CO)O)[N+](=O)[O-])NCCO
818-61-1 212-454-92-Hydroxyethyl acrylateOCCOC(=O)C=C
82-28-0 201-408-3C.I. Disperse orange 2 (1-amino-2-methyl-anthrquinone)Cc1ccc2C(=O)c3ccccc3C(=O)c2c1N
82-45-1 201-423-51-AminoanthraquinoneNc1cccc2C(=O)c3ccccc3C(=O)c12
823-40-5 212-513-92,6-Diaminotoluene (free base)Cc1c(cccc1N)N
82576-75-8 HC violet 1 - COLIPA B066[O-][N+](=O)c1cc(NCCO)c(cc1N)C
82617-23-0 Vinyl carbamate epoxideO=C(N)O[C@@H]1OC1
828-00-2 212-579-9Dimethoxane, commercial grade [AKA acetic acid ester with 2,6-dimethyl-m-dioxan-4-ol]CC1CC(OC(=O)C)OC(C)O1
838-88-0 212-658-84,4'-Methylene-bis(2-methylaniline)Cc1cc(Cc2ccc(N)c(C)c2)ccc1N
838-95-9 4-DimethylaminostilbeneCN(C)C1=CC=C(C=C1)/C=C/C2=CC=CC=C2
84-65-1 201-549-09,10-AnthraquinoneO=C1c2ccccc2C(=O)c3ccccc13
84041-77-0 281-856-4N,N'-Bis(hydroxyethyl)-2-nitro-p-phenylenediamine COLIPA B034OCCNc1ccc(NCCO)c(c1)[N+](=O)[O-]
842-07-9 212-668-2C.I. Solvent yellow 14Oc1ccc2ccccc2c1N=Nc3ccccc3
85-02-9 201-582-0Benzo(f)quinolinec1ccc2c(c1)ccc3ncccc23
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