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ECVAMes_Positives List: ECVAM Ames Positives List: EURL ECVAM Genotoxicity and Carcinogenicity Database of Ames Positive Chemicals This list of 726 chemicals derives from the EURL ECVAM database of curated in vitro and in vivo genotoxicity and carcinogenicity data for Ames positive chemicals, that was compiled from a variety of sources: EU and international regulatory agencies, industry and scientific literature databases. The database is intended to aid in the development and evaluation of alternative approaches to animal testing. It has already been used to evaluate the predictivity of the in vitro Ames test for in vivo genotoxicity and carcinogenicity when used alone or in combination with in vitro assays based on mammalian cells, and for a better characterisation of those cases where the Ames test leads to misleading ('false positive') results (Kirkland et al., Mutation Research, Volumes 775.776, Pages 69.80, 2014). 1 2 3 4 (723 chemicals) download  excel file 
CASEINECSChemical NameSMILES
121-14-2 204-450-02,4-DinitrotolueneCc1ccc(cc1[N+](=O)[O-])[N+](=O)[O-]
121-66-4 204-490-92-Amino-5-nitrothiazoleNc1ncc(s1)[N+](=O)[O-]
121-73-3 204-496-1m-Chloronitrobenezene[O-][N+](=O)c1cccc(Cl)c1
121-88-0 204-503-82-Amino-5-nitrophenolNc1ccc(cc1O)[N+](=O)[O-]
1211-40-1 4-Amino-4'-nitrobiphenylC1=CC(=CC=C1C2=CC=C(C=C2)[N+](=O)[O-])N
122-14-5 204-524-2FenitrothionCOP(=S)(OC)Oc1ccc(c(C)c1)[N+](=O)[O-]
122-60-1 204-557-2Phenylglycidyl etherC(Oc1ccccc1)C2CO2
122-66-7 204-563-5HydrazobenzeneN(Nc1ccccc1)c2ccccc2
124-48-1 204-704-0ChlorodibromomethaneClC(Br)Br
125-33-7 204-737-0Primaclone (primidone)CCC1(C(=O)NCNC1=O)c2ccccc2
125279-81-4 Glycidyl 4-nitrophenyl ether R-O1[C@H](C1)COc1ccc(cc1)[N+](=O)[O-]
126-72-7 204-799-9Tris(2,3-dibromopropyl)phosphateBrCC(Br)COP(=O)(OCC(Br)CBr)OCC(Br)CBr
126-85-2 Nitrogen mustard N-oxideN(CCCl)(CCCl)(C)=O
126-99-8 204-818-02-Chlorobuta-1,3-dieneClC(=C)C=C
127-00-4 204-819-61-Chloro-2-propanolCC(O)CCl
127-07-1 204-821-7HydroxyureaNC(=O)NO
128-04-1 204-876-7Sodium dimethyldithiocarbamate[Na+].CN(C)C(=S)[S-]
128-95-0 204-922-6Disperse violet 1/ Cl 61100 COLIPA C64Nc1ccc(N)c2C(=O)c3ccccc3C(=O)c12
128714-76-1 3,6-Dinitrobenzopyrene[O-][N+](=O)c2c5c4c(c1ccccc12)ccc3ccc([N+]([O-])=O)c(c34)cc5
129-00-0 204-927-3PyreneC1=CC2=C3C(C=CC4=CC=CC(C=C2)=C34)=C1
129-15-7 204-932-02-Methyl-1-nitroanthraquinoneCc1ccc2C(=O)c3ccccc3C(=O)c2c1[N+](=O)[O-]
129-17-9 204-934-1Blue VRS[Na+].CCN(CC)c1ccc(cc1)C(=C2C=CC(=[N+](CC)CC)C=C2)c3ccc(cc3S(=O)(=O)[O-])S(=O)(=O)[O-]
130-89-2 205-001-1Quinine (free base)[C@@H]12[C@H](CN([C@@H](C1)[C@@H](c1ccnc3c1cc(OC)cc3)O)CC2)C=C.Cl
13010-07-6 235-856-6N-Propyl-N'-nitro-N-nitrosoguanidineCCCN(N=O)C(=N)N[N+](=O)[O-]
13024-49-2 4-(2-Phenylethyl)anilineC1=CC=C(C=C1)CCC2=CC=C(C=C2)N
1314-84-7 215-244-5Zinc phosphide (Zinctox)P12[Zn]P([Zn]1)[Zn]2
131657-78-8 2-Chloro-6-ethylamino-4-nitrophenol - COLIPA B89Clc1cc(cc(NCC)c1O)[N+]([O-])=O
13171-21-6 236-116-5PhosphamidonCCN(CC)C(=O)\C(=C(/C)\OP(=O)(OC)OC)\Cl
132-32-1 205-057-73-Amino-9-ethyl carbazoleCCn1c2ccccc2c3cc(N)ccc13
13366-73-9 PhotodieldrinClC6C2(Cl)C4(Cl)C(Cl)(Cl)C6(Cl)C5C3C1OC1C(C23)C45
134-32-7 205-138-71-Naphthylamine [Japan]Nc1cccc2ccccc12
135-20-6 205-183-2Cupferron[NH4+].[O-]N(N=O)c1ccccc1
135-23-9 205-184-8Methapyrilene hydrochlorideCN(C)CCN(Cc1cccs1)c2ccccn2.Cl
135-68-2 205-211-34-Amino-4'-chlorobiphenylNc1ccc(cc1)c2ccc(Cl)cc2
13551-87-6 236-931-6MisonidazoleCOCC(O)Cn1ccnc1[N+](=O)[O-]
137-09-7 205-279-42,4-Diaminophenol 2HClc1(c(ccc(c1)N)O)N.Cl.Cl
137-17-7 205-282-02,4,5-Trimethylaniline (free base)Cc1cc(C)c(N)cc1C
137-26-8 205-286-2Thiram (tetramethulthiuram disulfide)CN(C)C(=S)SSC(=S)N(C)C
137-30-4 205-288-3Zinc dimethyldithiocarbamate (Ziram)CN(C)C(=S)S[Zn]SC(=S)N(C)C
13743-07-2 1-(2-Hydroxyethyl)-1-nitrosoureaC(CO)N(C(=O)N)N=O
13765-19-0 237-366-8Calcium chromate[Cr](=O)(=O)([O-])[O-].[Ca+2]
139-65-1 205-370-94,4'-ThiodianilineNc1ccc(Sc2ccc(N)cc2)cc1
139-94-6 205-387-1Nithiazide (1-Ethyl-3-(5-Nitrothiazol-2-Yl)UreaCCNC(=O)Nc1ncc(s1)[N+](=O)[O-]
13909-09-6 "1-(2-Chloroethyl)-3-(4-methylcyclohexyl) -1-nitrosourea (AKA Methyl CCNU)"O=C(NC1CCC(C)CC1)N(CCCl)N=O
14088-71-2 237-934-5Kilakar [Proclonol]OC(C1CC1)(c2ccc(Cl)cc2)c3ccc(Cl)cc3
142-83-6 205-564-32,4-HexadienalCC=CC=CC=O
144644-13-3 PEG-3-2',2'-di-p-phenylelenediamine COLIPA A146
146-59-8 205-675-7ICR 170CCN(CCCl)CCCNc1c2ccc(Cl)cc2nc3ccc(OC)cc13
14618-80-5 604-513-6R)-Benzyl glycidyl etherC(OCc1ccccc1)[C@H]2CO2
1464-53-5 215-979-1DiepoxybutaneC1OC1C2CO2
1465-25-4 215-981-2N-(1-Naphthyl)ethylenediamine 2HCl)c1ccc2c(c1)cccc2NCCN.Cl.Cl
14698-29-4 238-750-8Oxolinic acidCCN1C=C(C(=O)O)C(=O)c2cc3OCOc3cc12
147-94-4 205-705-9Cytosine arabinosideNC1=NC(=O)N(C=C1)[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O
148-24-3 205-711-18-Hydroxyquinolinec1cc2cccnc2c(c1)O
148-79-8 205-725-8Thiabendazolec1ccc2[nH]c(nc2c1)c3cscn3
148-82-3 205-726-3MelphalanN[C@@H](Cc1ccc(cc1)N(CCCl)CCCl)C(=O)O
14816-18-3 238-887-3Valexon / PhoximCCOP(=S)(OCC)O\N=C(/C#N)\c1ccccc1
150-75-4 205-768-2N-Methyl-4-aminophenolCNc1ccc(O)cc1
151-56-4 205-793-9Ethylene imine (AKA Aziridine)C1CN1
153-78-6 205-817-82-Aminofluorenec12c3c(cccc3)Cc1cc(N)cc2
154-93-8 205-838-2Carmustine [1,3-bis(2-chloroethyl)nitrosurea]ClCCNC(=O)N(CCCl)N=O
15403-45-9 3-3'-DibromomethoxybenzidineO=C(OC)c1cc(ccc1N)c2cc(C(=O)OC)c(N)cc2
156-10-5 205-848-7p-NitrosodiphenylamineO=Nc1ccc(Nc2ccccc2)cc1
156-51-4 205-856-0Phenylethylhydrazine sulphatec1ccc(cc1)CCNN.OS(=O)(=O)O
156-57-0 205-858-1Cysteamine hydrochlorideC(CS)N.Cl
156-62-7 205-861-8Calcium cyanamideC(#N)[NH2-2].[Ca+2]
15663-27-1 239-733-8Cisplatin[Pt+2]([NH3])([Cl-])([Cl-])[NH3]
1603-02-7 216-500-92,5,6-Triamino-4-Pyrimidinol sulfate - COLIPA A143Nc1nc(N)c(N)c(O)n1.OS(=O)(=O)O
16071-86-6 240-221-1C.I. Direct brown 95c1(c2ccc(\N=N\c3cc(c(O)cc3)C(=O)[O-])cc2)ccc(\N=N\c2c(c(\N=N\c3cc(ccc3[O-])S(=O)(=O)[O-])ccc2O)[O-])cc1.[Cu+2].[Na+].[Na+]
16219-98-0 2-NitrosomethylaminopyridineCN(C1=CC=CC=N1)N=O
16238-56-5 7-Bromomethyl-12-methylbenz[a]anthraceneBrCc3c4c(c(c2c1ccccc1ccc23)C)cccc4
16338-97-9 DiallylnitrosamineC=CCN(CC=C)N=O
1653-19-6 216-721-02,3-Dichlorobuta-1,3-dieneClC(=C)C(=C)Cl
16543-55-8 N-NitrosonornicotineC1CC(N(C1)N=O)C2=CN=CC=C2
1666-13-3 216-780-2Diphenyl diselenideC1=CC=C(C=C1)[Se][Se]C2=CC=CC=C2
16672-87-0 240-718-3EthephonOP(=O)(O)CCCl
16752-77-5 240-815-0Methomyl (AKA Lannate)CNC(=O)O\N=C(/C)\SC
16813-36-8 1-Nitroso-5,6-dihydrouracilO=C1NC(=O)N(N=O)CC1
1684-42-0 216-868-0Acranyl dihydrochlorideCCN(CC)CC(O)CNc1c2ccc(Cl)cc2nc3ccc(OC)cc13
17309-86-3 5-p-Dimethylaminophenylazoindazolen3cc2cc(/N=N/c1ccc(N(C)C)cc1)ccc2n3
1777-84-0 217-211-03-Nitro-p-acetophenetideCCOc1ccc(NC(=O)C)cc1[N+](=O)[O-]
1825-21-4 PentachloroanisoleClc1c(OC)c(Cl)c(Cl)c(Cl)c1Cl
1836-75-5 217-406-0Nitrofen[O-][N+](=O)c1ccc(Oc2ccc(Cl)cc2Cl)cc1
18463-85-9 6-(p-Dimethylaminophenylazo)benzthiazolen2c3ccc(/N=N/c1ccc(N(C)C)cc1)cc3sc2
18463-90-6 5-(p-Dimethylaminophenylazo)benzothiazolen2c3cc(/N=N/c1ccc(N(C)C)cc1)ccc3sc2
18774-85-1 N-HexylnitrosoureaO=C(N(N=O)CCCCCC)N
188696-80-2 AMP397C(NCc1c2[nH]c(c([nH]c2cc(c1)[N+](=O)[O-])=O)=O)P(=O)(O)O
18883-66-4 242-646-8StreptozotocinCN(N=O)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O
189-92-4 10-Azabenzo(a)pyrenec2cc3cc1cccnc1c4ccc5cccc2c5c34
1896-62-4 217-587-6Methyl trans-styryl ketoneCC(=O)\C=C\c1ccccc1
19010-66-3 242-748-2Lead dimethyldithiocarbamateCN(C)C1=S[Pb+2]2([SH-]C(=S2)N(C)C)[SH-]1
1937-37-7 217-710-3C.I. Direct black 38[Na+].[Na+].Nc1ccc(N=Nc2ccc(cc2)c3ccc(cc3)N=Nc4c(N)c5c(O)c(N=Nc6ccccc6)c(cc5cc4S(=O)(=O)[O-])S(=O)(=O)[O-])c(N)c1
19387-91-8 243-014-4TinidazoleCCS(=O)(=O)CCn1c(C)ncc1[N+](=O)[O-]
194-59-2 205-895-37H-Dibenzo[c,g]carbazolec1ccc2c(c1)ccc3[nH]c4ccc5ccccc5c4c23
1955-45-9 PivalolactoneO=C1OCC1(C)C
19622-55-0 Megazol (CL 64855)CN1C(=CN=C1C2=NN=C(S2)N)[N+](=O)[O-]
2051-62-9 218-127-74-MonochlorobiphenylClc1ccc(cc1)c2ccccc2
20702-77-6 243-978-6Neohesperidin dihydrochalconeO([C@H]1[C@H](O[C@H]2[C@@H]([C@@H]([C@@H](O)[C@@H](O2)C)O)O)[C@H]([C@H](O)[C@H](O1)CO)O)c1cc(c(C(CCc2cc(c(OC)cc2)O)=O)c(c1)O)O
20721-50-0 243-987-5Disperse black 9 COLIPA C106Nc1ccc(cc1)N=Nc2ccc(cc2)N(CCO)CCO
20830-81-3 244-069-7Daunomycin/ DaunorubicinCOc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)C
20917-49-1 NitrosoheptamethyleneimineO=NN1CCCCCCC1
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