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ECVAMes_Positives List: ECVAM Ames Positives List: EURL ECVAM Genotoxicity and Carcinogenicity Database of Ames Positive Chemicals This list of 726 chemicals derives from the EURL ECVAM database of curated in vitro and in vivo genotoxicity and carcinogenicity data for Ames positive chemicals, that was compiled from a variety of sources: EU and international regulatory agencies, industry and scientific literature databases. The database is intended to aid in the development and evaluation of alternative approaches to animal testing. It has already been used to evaluate the predictivity of the in vitro Ames test for in vivo genotoxicity and carcinogenicity when used alone or in combination with in vitro assays based on mammalian cells, and for a better characterisation of those cases where the Ames test leads to misleading ('false positive') results (Kirkland et al., Mutation Research, Volumes 775.776, Pages 69.80, 2014). 1 2 3 4 (723 chemicals) download  excel file 
CASEINECSChemical NameSMILES
100-00-5 202-809-61-Chloro-4-nitrobenzene[O-][N+](=O)c1ccc(Cl)cc1
100-01-6 202-810-1p-NitroanilineNc1ccc(cc1)[N+](=O)[O-]
100-17-4 202-825-3p-NitroanisoleCOc1ccc(cc1)[N+](=O)[O-]
100-44-7 202-853-6Benzyl chlorideClCc1ccccc1
100-63-0 202-873-5Phenylhydrazine (free base)NNc1ccccc1
100-75-4 202-886-6N-NitrosopiperidineO=NN1CCCCC1
100-97-0 202-905-8HexamethylenetetramineC1N2CN3CN1CN(C2)C3
10026-24-1 600-050-9Cobalt Sulfate heptahydrateO.O.O.O.O.O.O.[Co+2].OS(=O)(=O)O
10028-15-6 233-069-2Ozone[O-][O+]=O
10034-96-5 600-072-9Manganese (II) sulfate monohydrateO.[O-]S(=O)(=O)[O-].[Mn+2]
10048-13-2 233-158-6SterigmatocystinCOc1cc2OC3OC=CC3c2c4Oc5cccc(O)c5C(=O)c14
10049-04-4 233-162-8Chlorine dioxide[O]Cl=O |^1:0|
101-14-4 202-918-94,4'-Methylenebis(2-chloroaniline) (free base)Nc1ccc(Cc2ccc(N)c(Cl)c2)cc1Cl
101-61-1 202-959-24,4'-Methylenebis(N,N-dimethylaniline)CN(C)c1ccc(Cc2ccc(cc2)N(C)C)cc1
101-77-9 202-974-4Methylenedianiline/HClNc1ccc(Cc2ccc(N)cc2)cc1
101-80-4 202-977-04,4'-OxydianilineNc1ccc(Oc2ccc(N)cc2)cc1
101-90-6 202-987-5Diglycidyl resorcinol ether, technical gradeC(Oc1cccc(OCC2CO2)c1)C3CO3
10102-44-0 233-272-6Nitrogen dioxide[N](=O)=O
10108-64-2 233-296-7Cadmium chloride[Cd](Cl)Cl
101222-80-4 U-71,184CC1=CNC2=C1[C@@]13C[C@@H]1CN(C(=O)C1=CC4=C(N1)C=CC(NC(=O)C1=CC5=C(N1)C=CC=C5)=C4)C3=CC2=O
102-50-1 203-036-7m-CresidineCOc1ccc(N)c(C)c1
103-33-3 203-102-5Azobenzenec1ccc(cc1)N=Nc2ccccc2
10318-26-0 DibromodulcitolC(C(C(C(C(CBr)O)O)O)O)Br
104-94-9 203-254-2p-AnisidineCOc1ccc(N)cc1
105-11-3 203-271-5p-Quinone dioximeON=C1C=CC(=NO)C=C1
105-45-3 203-299-8Methyl acetoacetateCOC(=O)CC(=O)C
105650-23-5 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhiP - free base & HCl salt)c12c(nc(n2C)N)ncc(c1)c1ccccc1
10588-01-9 234-190-3Sodium dichromate[Cr](O[Cr](=O)(=O)[O-])(=O)(=O)[O-].[Na+].[Na+]
10595-95-6 NitrosoethylmethylamineCCN(C)N=O
106-47-8 203-401-0p-Chloroaniline (free base and HCl salt)Nc1ccc(Cl)cc1
106-50-3 203-404-7p- Phenylenediamine (COLIPA: A7) (free base)Nc1ccc(N)cc1
106-51-4 203-405-21,4- BenzoquinoneO=C1C=CC(=O)C=C1
106-88-7 203-438-21,2-EpoxybutaneCCC1CO1
106-89-8 203-439-8EpichlorhydrinClCC1CO1
106-91-2 203-441-92,3-Epoxypropyl methacrylateCC(=C)C(=O)OCC1CO1
106-92-3 203-442-4Allyl glycidyl etherC=CCOCC1CO1
106-93-4 203-444-51,2-DibromoethaneBrCCBr
106-94-5 203-445-01-BromopropaneCCCBr
106-99-0 203-450-81,3-ButadieneC=CC=C
10605-21-7 234-232-02-Benzimidazolecarbamate (AKA Carbendazim)COC(=O)Nc1nc2ccccc2[nH]1
106268-95-5 Glycidyl 4-nitrobenzoate RO=C(OC[C@H]1OC1)c2ccc([N+]([O-])=O)cc2
107-02-8 203-453-4AcroleinC=CC=O
107-05-1 203-457-6Allyl chloride (Chloropropene)ClCC=C
107-06-2 203-458-11,2-DichloroethaneClCCCl
107-07-3 203-459-7Ethylene chlorohydrin/ 2-chloroethanolOCCCl
107-13-1 203-466-5AcrylonitrileC=CC#N
107-19-7 203-471-2Propargyl alcohol OCC#C
107-20-0 203-472-8ChloroacetaldehydeClCC=O
107-22-2 203-474-9Glyoxal (40% in water)O=CC=O
108-45-2 203-584-7m-PhenylenediamineNc1cccc(N)c1
108-60-1 203-598-3Bis(2-chloro-1-methylethyl)ether, technical gradeCC(CCl)OC(C)CCl
1086-00-6 1-ChloromethylpyreneC1=CC2=C3C(=C1)C=CC4=C(C=CC(=C43)C=C2)CCl
109-70-6 203-697-11-Bromo-3-chloropropaneClCCCBr
109-84-2 203-711-62-HydroxyethylhydrazineNNCCO
110-57-6 203-779-7trans-1,4-Dichlorobutene-2C\C(=C(\C)/Cl)\Cl
110102-85-7 5-Amino-4-chloro-o-cresol-HCl -COLIPA A117Clc1cc(c(O)cc1N)C
11056-06-7 BleomycinO=C(N)[C@@H](N)CN[C@H](c1nc(N)c(c(n1)C(=O)N[C@H](C(=O)N[C@H](C)[C@@H](O)[C@@H](C(=O)N[C@H](C(=O)NCCc2nc(cs2)c3nc(C(=O)NCCC[S+](C)C)cs3)[C@H](O)C)C)C(O[C@@H]5O[C@@H](CO)[C@@H](O)[C@H](O)[C@@H]5O[C@H]4O[C@H](CO)[C@@H](O)[C@H](OC(=O)N)[C@@H]4O)c6cncn6)C)CC(=O)N
111-30-8 203-856-5"Glutaral; Glutaric dialdehyde solution, Pentane-1,5-dial ; protectol GDA; glutaraldehyde "O=CCCCC=O
111-41-1 203-867-5N-(Aminoethyl)ethanolamineNCCNCCO
111-44-4 203-870-1Bis-2-chloroethyletherClCCOCCCl
111-90-0 203-919-7Ethoxydiglycol CCOCCOCCO
111-91-1 203-920-2Bis(2-chloroethoxy)methaneClCCOCOCCCl
1116-54-7 214-237-4N-NitrosodiethanolamineOCCN(CCO)N=O
1120-71-4 214-317-91,3-Propane sultoneO=S1(=O)CCCO1
114-26-1 204-043-8PropoxurCNC(=O)Oc1ccccc1OC(C)C
114-83-0 204-055-31-Acetyl-2-phenylhydrazineCC(=O)NNc1ccccc1
115-02-6 204-061-6AzaserineO(C[C@@H](C(=O)O)N)C(=O)C=[N+]=[NH-]
115-07-1 204-062-1Propylene - PropeneCC=C
115-95-7 204-116-4Linalyl acetateCC(=CCCC(C)(OC(=O)C)C=C)C
1156-19-0 214-588-3TolazamideCc1ccc(cc1)S(=O)(=O)NC(=O)NN2CCCCCC2
1162-65-8 214-603-3Aflatoxin B1COc1cc2OC3OC=CC3c2c4OC(=O)C5=C(CCC5=O)c14
117-10-2 204-173-5DanthronOc1cccc2C(=O)c3cccc(O)c3C(=O)c12
117-39-5 204-187-1QuercetinOC1=C(Oc2cc(O)cc(O)c2C1=O)c3ccc(O)c(O)c3
117-79-3 204-208-42-AminoanthraquinoneNc1ccc2C(=O)c3ccccc3C(=O)c2c1
117907-43-4 2-Nitro-4-amino-diphenylamine-2???-carboxylic acid - COLIPA B87[O-][N+](=O)c2cc(ccc2Nc1c(C(=O)O)cccc1)N
118-71-8 204-271-8MaltolCC1=C(O)C(=O)C=CO1
118-75-2 204-274-42,3,5,6-Tetrachloro-1,4-benzoquinoneClC1=C(Cl)C(=O)C(=C(Cl)C1=O)Cl
119-34-6 204-316-14-Amino-2-nitrophenolNc1ccc(O)c(c1)[N+](=O)[O-]
119-90-4 204-355-43,3'-DimethoxybenzidineCOc1cc(ccc1N)c2ccc(N)c(OC)c2
119-93-7 204-358-03,3'-Dimethylbenzidine (free base)Cc1cc(ccc1N)c2ccc(N)c(C)c2
120-71-8 204-419-1p-CresidineCOc1ccc(C)cc1N
120-83-2 204-429-62,4-DichlorophenolOc1ccc(Cl)cc1Cl
12035-72-2 234-829-6Nickel subsulfide[Ni][Ni]\[Ni]=S=S
1204-41-7 4-Amino-2'-methylbiphenylCC1=CC=CC=C1C2=CC=C(C=C2)N
123-30-8 204-616-24-Aminophenol / p-aminophenol/ 4-hydroxyaniline COLIPA A16Nc1ccc(O)cc1
123-73-9 204-647-1CrotonaldehydeC\C=C\C=O
123-77-3 204-650-81,1'-AzobisformamideNC(=O)N=NC(=O)N
123219-86-3 U-73,975Cc1cnc2c1[C@]38C[C@@H]8CN(\C3=C\C2=O)C(=O)c4cc5cc(ccc5n4)NC(=O)c7coc6ccccc67
132885-85-9 4-(N-Ethyl-N-(2-hydroxyethyl)amino)-1-(2-hydroxyethyl)amino-2-nitrobenzene, monohydrochloride
133-06-2 205-087-0CaptanClC(Cl)(Cl)SN1C(=O)C2CC=CCC2C1=O
133-07-3 205-088-6N-(Trichloromethylthio)phthalimide [AKA FOLPET]ClC(Cl)(Cl)SN1C(=O)c2ccccc2C1=O
133-90-4 205-123-5Chlorambenc1c(cc(c(c1C(=O)O)Cl)N)Cl
140-49-8 205-416-84'-(Chloroacetyl)acetanilideCC(=O)Nc1ccc(cc1)C(=O)CCl
140-56-7 205-419-44-Dimethylaminobenzenediazosulfonic acid sodium salt (AKA fenaminosulf)S(\N=N\c1ccc(N(C)C)cc1)(=O)(=O)[O-].[Na+]
140-79-4 205-434-6DinitrosopiperazineO=NN1CCN(CC1)N=O
1401-20-3 604-173-9Safflower yellow
14047-09-7 3,3',4,4'-TetrachloroazobenzeneClc2ccc(/N=N/c1ccc(Cl)c(Cl)c1)cc2Cl
14064-55-2 (E)-4-Chloro-4'-nitrostilbeneC1=CC(=CC=C1/C=C/C2=CC=C(C=C2)Cl)[N+](=O)[O-]
14073-00-8 3-Methyl-4-nitroquinoline-N-oxidec12c(c(cn(=O)c1cccc2)C)[N+](=O)[O-]
14088-71-2 237-934-5Kilakar [Proclonol]OC(C1CC1)(c2ccc(Cl)cc2)c3ccc(Cl)cc3
149330-25-6 604-688-92,6-Dihydroxyethylaminotoluene - COLIPA A138Cc1c(NCCO)cccc1NCCO
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