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ECVAMes Positives List: ECVAM Ames Positives List: EURL ECVAM Genotoxicity and Carcinogenicity Database of Ames Positive Chemicals This list of 726 chemicals derives from the EURL ECVAM database of curated in vitro and in vivo genotoxicity and carcinogenicity data for Ames positive chemicals, that was compiled from a variety of sources: EU and international regulatory agencies, industry and scientific literature databases. The database is intended to aid in the development and evaluation of alternative approaches to animal testing. It has already been used to evaluate the predictivity of the in vitro Ames test for in vivo genotoxicity and carcinogenicity when used alone or in combination with in vitro assays based on mammalian cells, and for a better characterisation of those cases where the Ames test leads to misleading ('false positive') results (Kirkland et al., Mutation Research, Volumes 775.776, Pages 69.80, 2014). 1 2 3 (723 chemicals) download ECVAMes Positives List excel file 
CASEINECSJRC CODEChemical NameSMILES
100-01-6202-810-1JRC-000703p-NitroanilineNc1ccc(cc1)[N+](=O)[O-]
100-44-7202-853-6JRC-000706Benzyl chlorideClCc1ccccc1
106-50-3203-404-7JRC-000743p- Phenylenediamine (COLIPA: A7) (free base and 2HCl salt)Nc1ccc(N)cc1
106-91-2203-441-9JRC-0007372,3-Epoxypropyl methacrylateCC(=C)C(=O)OCC1CO1
108-60-1203-598-3JRC-000694Bis(2-chloro-1-methylethyl)ether, technical gradeCC(CCl)OC(C)CCl
1086-00-6-JRC-0011421-ChloromethylpyreneC1=CC2=C3C(=C1)C=CC4=C(C=CC(=C43)C=C2)CCl
1120-71-4214-317-9JRC-0007211,3-Propane sultoneO=S1(=O)CCCO1
117-79-3204-208-4JRC-0007282-AminoanthraquinoneNc1ccc2C(=O)c3ccccc3C(=O)c2c1
123-73-9204-647-1JRC-000671CrotonaldehydeC\C=C\C=O
123-77-3204-650-8JRC-0006721,1'-AzobisformamideNC(=O)N=NC(=O)N
101-80-4202-977-0JRC-0007764,4'-OxydianilineNc1ccc(Oc2ccc(N)cc2)cc1
10108-64-2233-296-7JRC-000066Cadmium chloride[Cd](Cl)Cl
101222-80-4-JRC-001141U-71,184CC1=CNC2=C1[C@@]13C[C@@H]1CN(C(=O)C1=CC4=C(N1)C=CC(NC(=O)C1=CC5=C(N1)C=CC=C5)=C4)C3=CC2=O
103-33-3203-102-5JRC-000685Azobenzenec1ccc(cc1)N=Nc2ccccc2
10588-01-9234-190-3JRC-001130Sodium dichromate and its dihydrate (VI)[Cr](O[Cr](=O)(=O)[O-])(=O)(=O)[O-].[Na+].[Na+]
106-94-5203-445-0JRC-0007401-BromopropaneCCCBr
107-13-1203-466-5JRC-000710AcrylonitrileC=CC#N
110102-85-7-JRC-0011385-Amino-4-chloro-o-cresol-HCl -COLIPA A117Clc1cc(c(O)cc1N)C
111-91-1203-920-2JRC-000647Bis(2-chloroethoxy)methaneClCCOCOCCCl
117-10-2204-173-5JRC-000729DanthronOc1cccc2C(=O)c3cccc(O)c3C(=O)c12
117-39-5204-187-1JRC-000730QuercetinOC1=C(Oc2cc(O)cc(O)c2C1=O)c3ccc(O)c(O)c3
117907-43-4-JRC-0011472-Nitro-4-amino-diphenylamine-2.-carboxylic acid - COLIPA B87[O-][N+](=O)c2cc(ccc2Nc1c(C(=O)O)cccc1)N
121-14-2204-450-0JRC-0006392,4-DinitrotolueneCc1ccc(cc1[N+](=O)[O-])[N+](=O)[O-]
122-60-1204-557-2JRC-000714Phenylglycidyl etherC(Oc1ccccc1)C2CO2
122-66-7204-563-5JRC-000715HydrazobenzeneN(Nc1ccccc1)c2ccccc2
125-33-7204-737-0JRC-000657Primaclone (primidone)CCC1(C(=O)NCNC1=O)c2ccccc2
100-17-4202-825-3JRC-000704p-NitroanisoleCOc1ccc(cc1)[N+](=O)[O-]
100-97-0202-905-8JRC-000109HexamethylenetetramineC1N2CN3CN1CN(C2)C3
10048-13-2233-158-6JRC-000744SterigmatocystinCOc1cc2OC3OC=CC3c2c4Oc5cccc(O)c5C(=O)c14
101-77-9202-974-4JRC-000775Methylenedianiline/HClNc1ccc(Cc2ccc(N)cc2)cc1
105-45-3203-299-8JRC-000667Methyl acetoacetateCOC(=O)CC(=O)C
10595-95-6-JRC-001119NitrosoethylmethylamineCCN(C)N=O
106-89-8203-439-8JRC-000736EpichlorhydrinClCC1CO1
10605-21-7234-232-0JRC-0003522-Benzimidazolecarbamate (AKA Carbendazim)COC(=O)Nc1nc2ccccc2[nH]1
106268-95-5-JRC-001146Glycidyl 4-nitrobenzoate R- and S-isomersO=C(OC[C@H]1OC1)c2ccc([N+]([O-])=O)cc2
114-83-0204-055-3JRC-0006781-Acetyl-2-phenylhydrazineCC(=O)NNc1ccccc1
118-71-8204-271-8JRC-000690MaltolCC1=C(O)C(=O)C=CO1
119-93-7204-358-0JRC-0006743,3'-Dimethylbenzidine (free base and 2HCl salt)Cc1cc(ccc1N)c2ccc(N)c(C)c2
126-85-2-JRC-001276Nitrogen mustard N-oxideC[N+](CCCl)(CCCl)[O-]
100-00-5202-809-6JRC-0007051-Chloro-4-nitrobenzene[O-][N+](=O)c1ccc(Cl)cc1
10028-15-6233-069-2JRC-001001Ozone[O-][O+]=O
10318-26-0-JRC-001143DibromodulcitolC(C(C(C(C(CBr)O)O)O)O)Br
104-94-9203-254-2JRC-000684p-Anisidine (free base and HCl salt)COc1ccc(N)cc1
106-51-4203-405-2JRC-0001111,4- BenzoquinoneO=C1C=CC(=O)C=C1
111-90-0203-919-7JRC-000646Ethoxydiglycol CCOCCOCCO
1116-54-7214-237-4JRC-000645N-NitrosodiethanolamineOCCN(CCO)N=O
115-02-6204-061-6JRC-000663AzaserineN[C@@H](COC(=O)C=[N+]=[N-])C(=O)O
119-34-6204-316-1JRC-0006894-Amino-2-nitrophenolNc1ccc(O)c(c1)[N+](=O)[O-]
1204-41-7-JRC-0011404-Amino-2'-methylbiphenylCC1=CC=CC=C1C2=CC=C(C=C2)N
123-30-8204-616-2JRC-0006734-Aminophenol / p-aminophenol/ 4-hydroxyaniline COLIPA A16Nc1ccc(O)cc1
123219-86-3-JRC-001144U-73,975Cc1cnc2c1[C@]38C[C@@H]8CN(\C3=C\C2=O)C(=O)c4cc5cc(ccc5n4)NC(=O)c7coc6ccccc67
125279-81-4-JRC-001150Glycidyl 4-nitrophenyl ether R- and S-isomersO1[C@H](C1)COc1ccc(cc1)[N+](=O)[O-]
10034-96-5600-072-9JRC-001137Manganese (II) sulfate monohydrate[O-]S(=O)(=O)[O-].[Mn+2]
101-90-6202-987-5JRC-000764Diglycidyl resorcinol ether, technical gradeC(Oc1cccc(OCC2CO2)c1)C3CO3
107-06-2203-458-1JRC-0004961,2-DichloroethaneClCCCl
107-07-3203-459-7JRC-000709Ethylene chlorohydrin/ 2-chloroethanolOCCCl
107-22-2203-474-9JRC-000707Glyoxal (40% in water)O=CC=O
114-26-1204-043-8JRC-000677PropoxurCNC(=O)Oc1ccccc1OC(C)C
1156-19-0214-588-3JRC-000644TolazamideCc1ccc(cc1)S(=O)(=O)NC(=O)NN2CCCCCC2
121-88-0204-503-8JRC-0006382-Amino-5-nitrophenolNc1ccc(cc1O)[N+](=O)[O-]
124-48-1204-704-0JRC-000658ChlorodibromomethaneClC(Br)Br
105-11-3203-271-5JRC-000668p-Quinone dioximeON=C1C=CC(=NO)C=C1
106-88-7203-438-2JRC-0007351,2-EpoxybutaneCCC1CO1
106-93-4203-444-5JRC-0007391,2-DibromoethaneBrCCBr
107-19-7203-471-2JRC-000711Propargyl alcohol OCC#C
109-70-6203-697-1JRC-0006791-Bromo-3-chloropropaneClCCCBr
11056-06-7-JRC-001145BleomycinO=C(N)[C@@H](N)CN[C@H](c1nc(N)c(c(n1)C(=O)N[C@H](C(=O)N[C@H](C)[C@@H](O)[C@@H](C(=O)N[C@H](C(=O)NCCc2nc(cs2)c3nc(C(=O)NCCC[S+](C)C)cs3)[C@H](O)C)C)C(O[C@@H]5O[C@@H](CO)[C@@H](O)[C@H](O)[C@@H]5O[C@H]4O[C@H](CO)[C@@H](O)[C@H](OC(=O)N)[C@@H]4O)c6cncn6)C)CC(=O)N
111-44-4203-870-1JRC-000650Bis-2-chloroethyletherClCCOCCCl
115-95-7204-116-4JRC-000662Linalyl acetateCC(=CCCC(C)(OC(=O)C)C=C)C
1162-65-8214-603-3JRC-000105Aflatoxin B1COc1cc2OC3OC=CC3c2c4OC(=O)C5=C(CCC5=O)c14
120-71-8204-419-1JRC-000659p-CresidineCOc1ccc(C)cc1N
121-73-3204-496-1JRC-000637m-Chloronitrobenezene[O-][N+](=O)c1cccc(Cl)c1
100-75-4202-886-6JRC-000702N-NitrosopiperidineO=NN1CCCCC1
10026-24-1600-050-9JRC-001016Cobalt Sulfate heptahydrateO.O.O.O.O.O.O.[Co].[O]S([O])(=O)=O |^1:8,10|
101-14-4202-918-9JRC-0007774,4'-Methylenebis(2-chloroaniline) (free base and 2HCl salt)Nc1ccc(Cc2ccc(N)c(Cl)c2)cc1Cl
101-61-1202-959-2JRC-0007744,4'-Methylenebis(N,N-dimethylaniline)CN(C)c1ccc(Cc2ccc(cc2)N(C)C)cc1
106-47-8203-401-0JRC-000742p-Chloroaniline (free base and HCl salt)Nc1ccc(Cl)cc1
106-92-3203-442-4JRC-000738Allyl glycidyl etherC=CCOCC1CO1
106-99-0203-450-8JRC-0007411,3-ButadieneC=CC=C
107-05-1203-457-6JRC-000708Allyl chloride (Chloropropene)ClCC=C
107-20-0203-472-8JRC-000712ChloroacetaldehydeClCC=O
111-41-1203-867-5JRC-000649N-(Aminoethyl)ethanolamineNCCNCCO
119-90-4204-355-4JRC-0006753,3'-Dimethoxybenzidine (free base and 2HCl salt) / o-dianisidineCOc1cc(ccc1N)c2ccc(N)c(OC)c2
120-83-2204-429-6JRC-0005332,4-DichlorophenolOc1ccc(Cl)cc1Cl
12035-72-2234-829-6JRC-001139Nickel subsulfide[Ni][Ni]\[Ni]=S=S
122-14-5204-524-2JRC-000713FenitrothionCOP(=S)(OC)Oc1ccc(c(C)c1)[N+](=O)[O-]
100-63-0202-873-5JRC-000696Phenylhydrazine (free base and HCl salt)NNc1ccccc1
10049-04-4233-162-8JRC-001015Chlorine dioxide[O]Cl=O |^1:0|
10102-44-0233-272-6JRC-001149Nitrogen dioxide[N](=O)=O
102-50-1203-036-7JRC-000731m-CresidineCOc1ccc(N)c(C)c1
107-02-8203-453-4JRC-000043AcroleinC=CC=O
108-45-2203-584-7JRC-000695m-PhenylenediamineNc1cccc(N)c1
109-84-2203-711-6JRC-0006802-HydroxyethylhydrazineNNCCO
110-57-6203-779-7JRC-000665trans-1,4-Dichlorobutene-2C\C(=C(\C)/Cl)\Cl
111-30-8203-856-5JRC-000648"Glutaral; Glutaric dialdehyde solution, Pentane-1,5-dial ; protectol GDA; glutaraldehyde "O=CCCCC=O
115-07-1204-062-1JRC-000664Propylene - PropeneCC=C
118-75-2204-274-4JRC-0006912,3,5,6-Tetrachloro-1,4-benzoquinoneClC1=C(Cl)C(=O)C(=C(Cl)C1=O)Cl
121-66-4204-490-9JRC-0006362-Amino-5-nitrothiazoleNc1ncc(s1)[N+](=O)[O-]
1211-40-1-JRC-0011484-Amino-4'-nitrobiphenylC1=CC(=CC=C1C2=CC=C(C=C2)[N+](=O)[O-])N
126-72-7204-799-9JRC-000634Tris(2,3-dibromopropyl)phosphateBrCC(Br)COP(=O)(OCC(Br)CBr)OCC(Br)CBr

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