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In vitro genotoxicity: Updated recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests This list has been first established following a recommendation made at the ECVAM workshop on ways to reduce the frequency of irrelevant positive results in mammalian cell genotoxicity tests1. It was considered important to identify chemicals that could be used in the evaluation of modified or new assays. In light of newly available data, the JRC's European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM), together with a group of experts, has revised its recommended list2 of genotoxic and non-genotoxic chemicals for assessing the performance of new or improved in vitro genotoxicity test methods. Recommendations were made to fit three different sets of characteristics: Group 1: chemicals that should be detected as positive in in vitro mammalian cell genotoxicity tests; Group2: chemicals that should give negative results in in vitro genotoxicity tests and routinely do give negative results in existing in vitro mammalian cell genotoxicity tests; Group 3: chemicals that should give negative results in in vitro mammalian cell genotoxicity tests, but have been reported to induce chromosomal aberrations or tk mutations in mouse lymphoma cells, often at high concentrations or at high levels of cytotoxicity. 1 2 (72 chemicals) download In vitro genotoxicity excel file 
CASEINECSJRC CODEChemical NameSMILES
113-92-8204-037-5-Chlorpheniramine maleateCN(C)CCC(c1ccc(Cl)cc1)c2ccccn2
114-07-8204-040-1-ErythomycinCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O
15356-70-4239-388-3-d,l-mentholCC(C)C1CCC(C)CC1O
53-96-3200-188-6JRC-0003082-Acetylaminofluorene CC(=O)Nc1ccc2c(Cc3ccccc23)c1
5989-27-5227-813-5-D-limoneneCC(=C)[C@@H]1CCC(=CC1)C
688046-61-9--PyriofenoneCC1=CC(=C(C(=C1C(=O)C2=C(C(=CN=C2OC)Cl)C)OC)OC)OC
10108-64-2233-296-7JRC-000066Cadmium chloride[Cd](Cl)Cl
108-78-1203-615-4-MelamineNc1nc(N)nc(N)n1
1212-29-9214-920-7-N,N-dicyclohexyl thioureaS=C(NC1CCCCC1)NC2CCCCC2
134-72-5205-154-4-Ephidrine sulphateCN[C@@H](C)[C@H](O)c1ccccc1
15663-27-1239-733-8JRC-000056Cisplatin[Pt+2]([NH3])([Cl-])([Cl-])[NH3]
67-72-1200-666-4-HexachloroethaneClC(Cl)(Cl)C(Cl)(Cl)Cl
78-42-2201-116-6-Tris(2-ethylhexyl)phosphateCCCCC(CC)COP(=O)(OCC(CC)CCCC)OCC(CC)CCCC
111-42-2203-868-0-DiethanolamineOCCNCCO
287714-41-4--RosuvastatinCC(C)C1=NC(=NC(=C1C=CC(CC(CC(=O)O)O)O)C2=CC=C(C=C2)F)N(C)S(=O)(=O)C
56-57-5200-281-1JRC-0008234-Nitroquinoline-N-oxide[O-][N+](=O)c1cc[n+]([O-])c2ccccc12
598-55-0209-939-2JRC-000536Methyl carbamateCOC(=O)N
62-75-9200-549-8JRC-000908DimethylnitrosamineCN(C)N=O
64-86-8200-598-5JRC-000007ColchicineCOC1=C(OC)C(OC)=C2C(CC[C@H](NC(C)=O)C3=CC(=O)C(OC)=CC=C23)=C1
78-84-2201-149-6-IsobutyraldehydeCC(C)C=O
122852-42-0--AlosteronCC1=C(N=CN1)CN2CCC3=C(C2=O)C4=CC=CC=C4N3C
124937-51-5--TolterodineOc1ccc(C)cc1[C@H](CCN(C(C)C)C(C)C)c2ccccc2
127-69-5204-858-9-SulfisoxazoleCc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C
147-94-4205-705-9JRC-000699Cytosine arabinosideNC1=NC(=O)N(C=C1)[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O
33419-42-0251-509-1JRC-000818EtoposideCOc1cc(cc(OC)c1O)[C@H]2[C@@H]3C(COC3=O)C(O[C@@H]4O[C@@H]5CO[C@@H](C)O[C@H]5[C@H](O)[C@H]4O)c6cc7OCOc7cc26
643-22-1211-396-1-Erythromycin stearateCCCCCCCCCCCCCCCCCC(=O)O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)O)O[C@H](C)C[C@@H]1N(C)C
759-73-9212-072-2JRC-000940ENUCCN(N=O)C(=O)N
100-51-6202-859-9-Benzyl alcoholOCc1ccccc1
109-69-3203-696-6-n-butyl chlorideCCCCCl
143-67-9205-606-0-Vinblastine sulfateCC[C@]1(O)C[C@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C2)(C(=O)OC)c5cc6c(cc5OC)N(C)[C@H]7[C@](O)([C@H](OC(=O)C)[C@]8(CC)C=CCN9CC[C@]67[C@H]89)C(=O)OC)C1
536-33-4208-628-9-EthionamideCCc1cc(ccn1)C(=S)N
57-13-6200-315-5JRC-000161UreaO=C(N)N
75-65-0200-889-7-Tert-butyl alcoholCC(C)(C)O
76180-96-6-JRC-001120IQ (2-amino-3methylimidazo[4,5-f]quinoline)Nc3nc2c(ccc1ncccc12)n3C
106-47-8203-401-0JRC-000742p-chloroanilineNc1ccc(Cl)cc1
1162-65-8214-603-3JRC-000105Aflatoxin B1COc1cc2OC3OC=CC3c2c4OC(=O)C5=C(CCC5=O)c14
118-92-3204-287-5-o-Anthranilic acidNc1ccccc1C(=O)O
1948-33-0217-752-2-Tertiary-butylhydroquinoneCC(C)(C)c1cc(O)ccc1O
30516-87-1-JRC-001022AzidothymidineCc1cn(c(=O)[nH]c1=O)[C@H]2C[C@@H]([C@H](O2)CO)N=[N+]=[N-]
33069-62-4608-826-9-TaxolCC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(=O)C)[C@H]2[C@H](OC(=O)c4ccccc4)[C@]5(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c6ccccc6)c7ccccc7)C(=C1C5(C)C)C
50-07-7200-008-6JRC-000833Mitomycin CCO[C@]12[C@H]3N[C@H]3CN1C4=C([C@H]2COC(=O)N)C(=O)C(=C(C)C4=O)N
57-97-6200-359-5JRC-0009027,12-DimethylbenzanthraceneCc1c2ccccc2c(C)c3c1ccc4ccccc34
6055-19-2-JRC-001080CyclophosphamideC1CNP(=O)(OC1)N(CCCl)CCCl.O
643-22-1211-396-1-erythromycin stearateCCCCCCCCCCCCCCCCCC(=O)O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)O)O[C@H](C)C[C@@H]1N(C)C
69-65-8200-711-8JRC-001310D-mannitolOC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
834-28-6212-637-3-Phenformin HClc1ccc(cc1)CCNC(=N)NC(=N)N.Cl
91374-21-9618-737-7-RopiniroleCCCN(CCC)CCc1cccc2NC(=O)Cc12
94-96-2202-377-9-2-Ethyl-1,3-hexanediolCCC[C@@H](O)[C@H](CC)CO
95-80-7202-453-1JRC-0010072,4-diaminotolueneCc1ccc(N)cc1N
97-77-8202-607-8JRC-000501Tetraethylthiuram disulfide [AKA disulfiram]CCN(CC)C(=S)SSC(=S)N(CC)CC
97240-79-4619-263-3-TopiramateCC1(C)O[C@@H]2CO[C@@]3(COS(=O)(=O)N)OC(C)(C)O[C@H]3[C@@H]2O1
107753-78-6--ZafirlukastCc1ccccc1S(=O)(=O)NC(=O)c5ccc(Cc3cn(C)c2ccc(cc23)NC(=O)OC4CCCC4)c(OC)c5
110-86-1203-809-9-Pyridinec1ccncc1
117-81-7204-211-0JRC-000177Di-(2-ethylhexyl)phthalateCCCCC(CC)COC(=O)C1=C(C=CC=C1)C(=O)OCC(CC)CCCC
124-64-1204-707-7-Tetrakis(hydroxymethyl) phosphonium chloride[Cl-].OC[P+](CO)(CO)CO
134-71-4205-153-9-Ephedrine hydrochlorideCNC(C)C(O)c1ccccc1
140-88-5205-438-8-Ethyl acrylateCCOC(=O)C=C
7784-46-5232-070-5JRC-000251Sodium arsenite[Na]O[As]=O
999-81-5213-666-4-(2-chloroethyl)trimethyl-ammonium chlorideC[N+](C)(C)CCCl
100-02-7202-811-7JRC-000327p-NitrophenolOc1ccc(cc1)[N+](=O)[O-]
105650-23-5-JRC-0011312-amino-1-methyl-6-phenylimidazo[4,5-b]pyridinec12c(nc(n2C)N)ncc(c1)c1ccccc1
108-46-3203-585-2JRC-0001311,3-Dihydroxybenzene (resorcinol)Oc1cccc(O)c1
123-31-9204-617-8-HydroquinoneOc1ccc(O)cc1
128-44-9204-886-1-Sodium saccharinO=C1NS(=O)(=O)c2ccccc12
50-32-8200-028-5JRC-000100Benzo[a]pyrenec1ccc2c(c1)cc3ccc4cccc5ccc2c3c45
51-21-8200-085-6JRC-0000645-FluorouracilFC1=CNC(=O)NC1=O
61-82-5200-521-5-AmitroleNc1nnc[nH]1
66-27-3200-625-0JRC-000919MMSCOS(=O)(=O)C
68291-97-4614-395-8-Zonisamide NS(=O)(=O)Cc1noc2ccccc12
7177-48-2615-347-9JRC-001311Ampicillin trihydrateCC1([C@@H](N2[C@H](S1)[C@H](C2=O)NC(=O)[C@@H](c3ccccc3)N)C(=O)O)C.O.O.O
97-53-0202-589-1-EugenolCOc1cc(CC=C)ccc1O

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