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FP6 ReProTect: Test chemicals used for the development of in vitro tests within the FP6 project .ReProTect The list was created for test developers participating in the FP 6 project ReProTect. This list contains more than 130 reproductive toxicants covering different target cells and toxicological mechanisms. The substances have been selected according to predefined criteria and were independently peer reviewed. 1 2 (133 chemicals) download FP6 ReProTect excel file 
CASEINECSJRC CODEChemical NameSMILES
117-81-7204-211-0JRC-000177Dioctyl PhthalateCCCCC(CC)COC(=O)C1=C(C=CC=C1)C(=O)OCC(CC)CCCC
129731-10-8--Vorozole[C@@H](c1cc2c(cc1)nnn2C)(c1ccc(cc1)Cl)n1cncn1
148-82-3205-726-3JRC-000666MelphalanN[C@@H](Cc1ccc(cc1)N(CCCl)CCCl)C(=O)O
302-79-4206-129-0-TretinoinC\C(=C/C=C/C(=C/C(=O)O)/C)\C=C\C1=C(C)CCCC1(C)C
330-55-2206-356-5JRC-000206LinuronCON(C)C(=O)NC1=CC(Cl)=C(Cl)C=C1
361-09-1206-643-5-Sodium CholateC[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C
50-22-6200-019-6JRC-000183Corticosterone[H][C@@]12CC[C@H](C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C
56-53-1200-278-5JRC-000191DiethylstilbestrolCC\C(=C(\CC)C1=CC=C(O)C=C1)C1=CC=C(O)C=C1
562-10-7209-228-7-Doxylamine Hydrogen SuccinateCN(C)CCOC(C)(c1ccccc1)c2ccccn2.OC(=O)CCC(=O)O
57-83-0200-350-6JRC-000220Progesterone[H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C
625-45-6210-894-6-Methoxyacetic AcidCOCC(=O)O
66-27-3200-625-0JRC-000919Methyl MethanesulphonateCOS(=O)(=O)C
10108-64-2233-296-7JRC-000066Cadmium Chloride[Cd](Cl)Cl
106-89-8203-439-8JRC-000736Oxirane, 2-(Chloromethyl)-ClCC1CO1
10605-21-7234-232-0JRC-000352Carbamic Acid, N-1h-Benzimidazol-2-Yl-, Methyl EsterCOC(=O)Nc1nc2ccccc2[nH]1
127-07-1204-821-7JRC-000701HydrixycarbamideNC(=O)NO
23214-92-8245-495-6JRC-000784DoxorubicinCOc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
446-72-0207-174-9JRC-000201 GenisterinOc1ccc(cc1)C2=COc3cc(O)cc(O)c3C2=O
4901-51-3225-531-7-2,3,4,5-TetrachlorophenolOc1cc(Cl)c(Cl)c(Cl)c1Cl
50-07-7200-008-6JRC-000833MitomycinCO[C@]12[C@H]3N[C@H]3CN1C4=C([C@H]2COC(=O)N)C(=O)C(=C(C)C4=O)N
55-98-1200-250-2JRC-000239BusulfanC[S](=O)(=O)OCCCCO[S](C)(=O)=O
631-64-1211-165-5JRC-000922Dibromoacetic AcidOC(=O)C(Br)Br
67-68-5200-664-3JRC-000001Dimethyl SulfoxideCS(=O)C
69-57-8200-710-2-Sodium [2s-(2?,5?,6?)]-3,3-Dimethyl-7-Oxo-6-(Phenylacetamido)-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylate[Na+].CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)[O-]
118949-22-7--Vorozolec1([C@@H](n2cncn2)c2ccc(cc2)Cl)ccc2nnn(c2c1)C
13311-84-7236-341-9JRC-000199FlutamideCC(C)C(=O)NC1=CC(=C(C=C1)[N](=O)=O)C(F)(F)F
1836-75-5217-406-0JRC-000275Benzene, 2,4-Dichloro-1-(4-Nitrophenoxy)-[O-][N+](=O)c1ccc(Oc2ccc(Cl)cc2Cl)cc1
31430-18-9250-626-5-NocodazoleCOC(=O)Nc1nc2cc(ccc2[nH]1)C(=O)c3cccs3
33069-62-4608-826-9-Benzenepropanoic Acid, ?-(Benzoylamino)-?-Hydroxy-, (2ar,4s,4as,6r,9s,11s,12s,12ar,12bs)-6,12b-Bis(Acetyloxy)-12-(Benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-Dodecahydro-4,11-Dihydroxy-4a,8,13,13-Tetramethyl-5-Oxo-7,11-Methano-1h-Cyclodeca[3,4]Benz[1,2-BCC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(=O)C)[C@H]2[C@H](OC(=O)c4ccccc4)[C@]5(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c6ccccc6)c7ccccc7)C(=C1C5(C)C)C
481-30-1--EpitestosteroneC1[C@@H]2[C@@H]([C@@]3(C(=CC(=O)CC3)C1)C)CC[C@@]1([C@H]2CC[C@H]1O)C
52806-53-8-JRC-000203Hydroxyflutamidec1c(C(F)(F)F)c([N+](=O)[O-])ccc1NC(=O)C(O)(C)C
53-86-1200-186-5JRC-000997IndometacinCOc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(O)=O)c2c1
55-29-3--DDT (P,P'-DDT)C(c1ccc(cc1)Cl)(c1ccc(cc1)Cl)C(Cl)(Cl)Cl
58-18-4200-366-3JRC-000209Methyltestosterone[H][C@@]12CC[C@](C)(O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C
592-62-1209-765-7JRC-000909(Methyl-Onn-Azoxy)Methyl AcetateCC(=O)OCN=[N+](C)[O-]
608-73-1210-168-9-HCHClC1C(Cl)C(Cl)C(Cl)C(Cl)C1Cl
61-25-6200-502-1-Papaverine Hydrochloridec12c(cc(c(c2)OC)OC)ccnc1Cc1cc(c(cc1)OC)OC.Cl
64-86-8200-598-5JRC-000007ColchicineCOC1=C(OC)C(OC)=C2C(CC[C@H](NC(C)=O)C3=CC(=O)C(OC)=CC=C23)=C1
65277-42-1265-667-4JRC-000205KetoconazoleCC(=O)N1CCN(CC1)C1=CC=C(OC[C@H]2CO[C@@](CN3C=CN=C3)(O2)C2=C(Cl)C=C(Cl)C=C2)C=C1
100-25-4202-833-7-1,4-Dinitrobenzene[O-][N+](=O)c1ccc(cc1)[N+](=O)[O-]
105-45-3203-299-8JRC-000667Methyl AcetoacetateCOC(=O)CC(=O)C
120-83-2204-429-6JRC-000533Phenol, 2,4-Dichloro-Oc1ccc(Cl)cc1Cl
129453-61-8-JRC-000403Fulvestrantc1cc2c(cc1O)C[C@@H](CCCCCCCCC[S@@](CCCC(C(F)(F)F)(F)F)=O)[C@H]1[C@H]3[C@](C)(CC[C@H]21)[C@@H](O)CC3
15663-27-1239-733-8JRC-000056Platinum, Diamminedichloro-, (Sp-4-2)-[Pt+2]([NH3])([Cl-])([Cl-])[NH3]
26571-11-9247-816-5-26-(Nonylphenoxy)-3,6,9,12,15,18,21,24-Octaoxahexacosan-1-OlCCCCCCCCCc1ccc(OCCOCCOCCOCCOCCOCCOCCOCCOCCO)cc1
303-45-7--Gossypolc1(c(c2c(cc1C)c(c(c(c2C=O)O)O)C(C)C)O)c1c(c2c(c(c(c(c2C=O)O)O)C(C)C)cc1C)O
50471-44-8256-599-6JRC-000232VinclozolinCC1(OC(=O)N(C1=O)C1=CC(Cl)=CC(Cl)=C1)C=C
51-21-8200-085-6JRC-000064FluorouracilFC1=CNC(=O)NC1=O
531-95-3208-522-2-(S)-3,4-Dihydro-3-(4-Hydroxyphenyl)-2h-1-Benzopyran-7-OlC1[C@H](c2ccc(cc2)O)Cc2ccc(cc2O1)O
60-51-5200-480-3JRC-000885DimethoateCNC(=O)CSP(=S)(OC)OC
66-81-9200-636-0JRC-000008Cicloheximide[H][C@]1(C[C@@H](C)C[C@H](C)C1=O)[C@H](O)CC1CC(=O)NC(=O)C1
69-72-7200-712-3JRC-001094Salicylic AcidOC(=O)c1ccccc1O
70-30-4200-733-8JRC-000088HexachloropheneOC1=C(Cl)C=C(Cl)C(Cl)=C1CC1=C(Cl)C(Cl)=CC(Cl)=C1O
10540-29-1234-118-0JRC-000227TamoxifenC(=C(/c1ccccc1)CC)(\c1ccc(OCCN(C)C)cc1)c1ccccc1
148-18-5205-710-6-Sodium Diethyldithiocarbamate[Na+].CCN(CC)C(=S)[S-]
2079-89-2218-208-7-Bis(3-Aminopropiononitrile) FumarateNCCC#N.NCCC#N.OC(=O)\C=C\C(=O)O
50-28-2200-023-8JRC-000226Estradiol[C@H]12[C@H]3[C@@H](c4c(CC3)cc(cc4)O)CC[C@@]1([C@H](CC2)O)C
521-18-6208-307-3JRC-000172Androstanolone[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])CC(=O)CC[C@]12C
56092-82-1611-357-2-Ionomycin[Ca+2].C(=O)(CC[C@H](C[C@H](C)C[C@@H](C(\C=C(\[C@H](C)C[C@@H](C\C=C\[C@H]([C@H]([C@H]([C@H](C[C@@H]1CC[C@@](O1)([C@@H]1O[C@@](CC1)([C@@H](C)O)C)C)O)C)O)C)C)[O-])=O)C)C)[O-]
58-55-9200-385-7JRC-000021TheophyllineO=C2C=1/N=C\NC=1N(C)C(=O)N2C
637-07-0211-277-4-ClofibrateCCOC(=O)C(C)(C)Oc1ccc(Cl)cc1
64-17-5200-578-6JRC-000070EthanolC(C)O
68-23-5200-682-1JRC-000234Noretynodrel[H][C@@]12CC[C@@](O)(C#C)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])CC(=O)CC3
68047-06-3-JRC-000165Trans-4-Hydroxytamoxifenc1c(O)ccc(\C(c2ccc(cc2)OCCN(C)C)=C(\c2ccccc2)CC)c1
115-09-3204-064-2JRC-000273Mercury, Chloromethyl- (8ci,9ci)C[Hg]Cl
125-84-8204-756-4-AminoglutethimideCCC1(CCC(=O)NC1=O)c2ccc(N)cc2
1397-94-0-JRC-000419Antimycin-AC1([C@@H]([C@H]([C@@H](OC(=O)[C@H]([C@H](O1)C)NC(c1c(c(ccc1)NC=O)O)=O)C)OC(CC(C)C)=O)CCCCCC)=O
15687-27-1239-784-6JRC-000269Benzeneacetic Acid, α-Methyl-4-(2-Methylpropyl)-CC(C)Cc1ccc(cc1)C(C)C(=O)O
17230-88-5241-270-1-DanazolC[C@]12Cc3cnoc3C=C1CC[C@@H]4[C@@H]2CC[C@@]5(C)[C@H]4CC[C@@]5(O)C#C
1912-24-9217-617-8JRC-000175AtrazineCCNc1nc(Cl)nc(NC(C)C)n1
58-22-0200-370-5JRC-000228Testosterone[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C
58-89-9200-401-2JRC-000069LindaneCl[C@@H]1[C@H](Cl)[C@@H](Cl)[C@H](Cl)[C@H](Cl)[C@H]1Cl
627-03-2210-978-2-Ethoxyacetic AcidCCOCC(=O)O
71-43-2200-753-7JRC-000046Benzenec1ccccc1
7232-21-5230-634-5-4-Amino-5-Chloro-N-[2-(Diethylamino)Ethyl]-2-Methoxybenzamide MonohydrochlorideCl.CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC
103-90-2203-157-5JRC-0000024-Acetamidophenolc1(ccc(cc1)O)NC(=O)C
106-48-9203-402-6-4-ChlorophenolOc1ccc(Cl)cc1
109-86-4203-713-7-Ethanol, 2-Methoxy-COCCO
118968-41-5--Org31710O1[C@@]2(CCC1)CC[C@@H]1[C@]2(C)C[C@H](c2ccc(cc2)N(C)C)C2=C3C([C@@H](C[C@@H]12)C)=CC(CC3)=O
1405-41-0215-778-9JRC-000423Gentamicin, Sulfate (Salt)CN[C@@H]1[C@@H](O)[C@@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H](CN)CC[C@H]3N)[C@@H]2O)OC[C@]1(C)O
1806-26-4217-302-5-Phenol, 4-Octyl-CCCCCCCCc1ccc(O)cc1
36322-90-4252-974-3-PiroxicamCN1C(=C(O)c2ccccc2S1(=O)=O)C(=O)Nc3ccccn3
3810-74-0223-286-0JRC-000455Streptomycin SulphateCN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]2[C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](NC(=N)N)[C@@H](O)[C@@H]3NC(=N)N)O[C@@H](C)[C@]2(O)C=O
4376-20-9224-477-1-Phthalic Acid, Mono-2-Ethyl Hexyl EsterCCCCC(CC)COC(=O)c1ccccc1C(O)=O
50-02-2200-003-9JRC-000187Dexamethasone[H][C@@]12C[C@@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C
54-36-4200-206-2-MetyraponeCC(C)(C(=O)c1cccnc1)c2cccnc2
57-63-6200-342-2JRC-000049Ethinylestradiol[H][C@@]12CC[C@@](O)(C#C)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])C=C(O)C=C3
58-08-2200-362-1JRC-000005CaffeineO=C1C2=C(N=CN2C)N(C(=O)N1C)C
63-05-8200-554-5JRC-000163Androst-4-Ene-3,17-Dione[H][C@@]12CCC(=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C
64-67-5200-589-6JRC-001005Diethyl SulphateCCOS(=O)(=O)OCC
67747-09-5266-994-5JRC-000410ProchlorazCCCN(CCOC1=C(Cl)C=C(Cl)C=C1Cl)C(=O)N1C=CN=C1
11018-89-6--OuabainC12([C@@H]3C(C4(C(C[C@H]3O)([C@H](CC4)C3=CC(=O)OC3)C)O)CCC1(C[C@H](C[C@H]2O)OC1C(C(C(C(O1)C)O)O)O)O)CO.O.O.O.O.O.O.O.O
26628-22-8247-852-1JRC-000224Sodium Azide (Na(N3))[N-]=[N+]=[N-].[Na+]
303-47-9206-143-7JRC-000058Ochratoxin A (7ci)C[C@@H]1CC2=C(Cl)C=C(C(=O)N[C@@H](CC3=CC=CC=C3)C(O)=O)C(O)=C2C(=O)O1
50-32-8200-028-5JRC-000100Benzo[Def]Chrysenec1ccc2c(c1)cc3ccc4cccc5ccc2c3c45
51-28-5200-087-7JRC-0003262,4-Dinitrophenolc1(cc(ccc1O)[N+](=O)[O-])[N+](=O)[O-]
52-67-5200-148-8-PenicillamineCC(C)(S)[C@@H](N)C(O)=O
521-11-9208-302-6JRC-000412Mestanolone[H][C@@]12CC[C@](C)(O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])CC(=O)CC[C@]12C
54-31-9200-203-6-FurosemideNS(=O)(=O)c1cc(C(=O)O)c(NCc2occc2)cc1Cl
67-64-1200-662-2-AcetoneCC(=O)C

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