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ECVAM 3T3NRU CITOTOXICITY: Reference chemicals used in the ECVAM validation study of the 3T3 NRU basal cytotoxicity assay to identify non-classified chemicals on the basis of the 2000 mg/kg b.w. threshold. The aim of this ECVAM Validation Study was to assess the capacity of the 3T3 Neutral Red Uptake (3T3 NRU) basal cytotoxicity assay to identify substances not requiring classification for acute oral systemic toxicity according to the EU Classification, Labelling and Packaging system (CLP) (i.e. oral LD50 > 2000 mg/kg). 56 chemicals were tested 1 (56 chemicals) download ECVAM 3T3NRU CITOTOXICITY excel file 
CASEINECSJRC CODEChemical NameSMILES
110-97-4203-820-9JRC-000117DiisopropanolamineCC(O)CNCC(C)O
112-07-2203-933-3JRC-0001392-Butoxyethyl acetateCCCCOCCOC(C)=O
141-97-9205-516-1JRC-000108Ethyl acetoacetateCCOC(=O)CC(=O)C
79-94-7201-236-9JRC-0001372,2',6,6'-Tetrabromo-4,4'-IsopropylidenediphenolOc(c(cc(c1)C(c(cc(c(O)c2Br)Br)c2)(C)C)Br)c1Br
106-51-4203-405-2JRC-000111p-BenzoquinoneO=C1C=CC(=O)C=C1
109-77-3203-703-2JRC-000159MalononitrileN#CCC#N
110-16-7203-742-5JRC-000148Maleic acidO=C(O)C=CC(=O)O
131-17-9205-016-3JRC-000143Diallyl phthalateC=CCOC(=O)C1=C(C=CC=C1)C(=O)OCC=C
2386-87-0219-207-4JRC-000112Diepoxide 126O=C(OCC1CCC2OC2C1)C1CCC2OC2C1
25646-77-9247-162-0JRC-000132(4-ammonio-m-tolyl)ethyl(2-hydroxyethyl)ammonium sulphatec1(cc(c(cc1)N)C)N(CCO)CC.S(=O)(=O)(O)O
26761-40-0247-977-1JRC-000144Di-'isodecyl' phthalatec1(c(cccc1)C(OCCCCCCCC(C)C)=O)C(OCCCCCCCC(C)C)=O
557-05-1209-151-9JRC-000154Zinc Distearate[Zn](OC(=O)CCCCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCCCC
579-66-8209-445-7JRC-0001502,6-DiethylanilineCCc1cccc(CC)c1N
68515-48-0271-090-9JRC-0001201,2-Benzenedicarboxylic Acid, Di-C8-10-Branched Alkyl Esters, C9-RichO=C(c1ccccc1C(=O)OCCCCCCCCC)OCCCCCCCCC
92-43-3202-155-1JRC-0001231-Phenyl-3-PyrazolidoneO=C1CCN(N1)C1=CC=CC=C1
98-86-2202-708-7JRC-000107AcetophenoneCC(=O)c1ccccc1
100-97-0202-905-8JRC-000109MethenamineC1N2CN3CN1CN(C2)C3
10361-37-2233-788-1JRC-000149Barium Chloride (BaCl2)[Ba](Cl)Cl
12125-02-9235-186-4JRC-000152Ammonium Chloride ((NH4)Cl)[NH4+].[ClH-]
122-99-6204-589-7JRC-0001452-phenoxyethanolOCCOc1ccccc1
3926-62-3223-498-3JRC-000118Sodium salt of chloroacetic acid[O-]C(CCl)=O.[Na+]
7779-90-0231-944-3JRC-000158Trizinc Bis(Orthophosphate)P([O-])([O-])(=O)[O-].P(=O)([O-])([O-])[O-].[Zn+2].[Zn+2].[Zn+2]
917-61-3213-030-6JRC-000119Sodium CyanateC(#N)O[Na]
108-46-3203-585-2JRC-000131ResorcinolOc1cccc(O)c1
121-87-9204-502-2JRC-0001402-chloro-4-nitroanilineNC1=C(Cl)C=C(C=C1)[N](=O)=O
134-32-7205-138-7JRC-0001471-naphthylamineNc1cccc2ccccc12
26523-78-4247-759-6JRC-000138Tris(nonylphenyl) phosphiteCCCCCCCCCC(C=C1)=CC=C1OP(OC2=CC=C(CCCCCCCCC)C=C2)OC3=CC=C(CCCCCCCCC)C=C3
357-57-3206-614-7JRC-000126Brucine[H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6C7=CC(OC)=C(OC)C=C7[C@@]1(CC[N@]2C4)[C@]6([H])[C@@]35[H]
100-52-7202-860-4JRC-000157BenzaldehydeO=Cc1ccccc1
105-39-5203-294-0JRC-000114Ethyl chloroacetateCCOC(=O)CCl
124-07-2204-677-5JRC-000141Caprylic acidO=C(O)CCCCCCC
57-13-6200-315-5JRC-000161UreaO=C(N)N
7758-98-7231-847-6JRC-000153Copper SulphateO1S(=O)(=O)O[Cu]1
81-14-1201-328-9JRC-0001154'-Tert-Butyl-2',6'-Dimethyl-3',5'-DinitroacetophenoneCC(=O)C1=C(C)C(=C(C(=C1C)[N](=O)=O)C(C)(C)C)[N](=O)=O
85-44-9201-607-5JRC-000136Phthalic AnhydrideO=C1OC(=O)c2ccccc12
90-72-2202-013-9JRC-0001062,4,6-Tris(Dimethylaminomethyl)PhenolOc(c(cc(c1)CN(C)C)CN(C)C)c1CN(C)C
95-50-1202-425-9JRC-0001291,2-Dichlorobenzenec1(c(cccc1)Cl)Cl
101-72-4202-969-7JRC-000121N-isopropyl-N'-phenyl-p-phenylenediamineCC(C)NC1=CC=C(NC2=CC=CC=C2)C=C1
302-27-2206-121-7JRC-000151AconitineCCN1C[C@]2(COC)[C@H](O)C[C@H](OC)[C@@]34[C@@H]5C[C@]6(O)[C@@H](OC)[C@H](O)[C@](OC(=O)C)([C@@H]([C@H](OC)[C@H]23)C14)[C@H]5[C@H]6OC(=O)c7ccccc7
102-76-1203-051-9JRC-000155Glycerol triacetateCC(=O)OCC(COC(C)=O)OC(C)=O
109-16-0203-652-6JRC-000134Triethylene glycol dimethacrylateCC(=C)C(=O)OCCOCCOCCOC(=O)C(C)=C
120-82-1204-428-0JRC-0001271,2,4-trichlorobenzeneClc1ccc(Cl)c(Cl)c1
91-53-2202-075-7JRC-000116EthoxyquinCCOc1ccc2NC(C)(C)C=C(C)c2c1
102-71-6203-049-8JRC-000146TriethanolamineN(CCO)(CCO)CCO
103-11-7203-080-7JRC-0001562-ethylhexyl acrylateCCCCC(CC)COC(=O)C=C
1034-01-1213-853-0JRC-000130Octyl 3,4,5-trihydroxybenzoateCCCCCCCCOC(=O)C1=CC(O)=C(O)C(O)=C1
107-64-2203-508-2JRC-000135Dimethyldioctadecylammonium chlorideCCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC
112-34-5203-961-6JRC-0001102-(2-butoxyethoxy)ethanolCCCCOCCOCCO
120-51-4204-402-9JRC-000142Benzyl benzoateO=C(OCc1ccccc1)c2ccccc2
1314-13-2215-222-5JRC-000133Zinc Oxide (Zno)[Zn]=O
1338-39-2215-663-3JRC-000124Sorbitan monolaurateO1[C@@H]([C@H]([C@@H](O)C1)O)[C@H](COC(CCCCCCCCCCC)=O)O
60-00-4200-449-4JRC-000125Edetic AcidO=C(O)CN(CCN(CC(=O)O)CC(=O)O)CC(=O)O
7778-80-5231-915-5JRC-000122Potassium SulfateS(=O)(=O)([O-])[O-].[K+].[K+]
866-84-2212-755-5JRC-000160Tripotassium CitrateC(CC(=O)[O-])(CC(=O)[O-])(C(=O)[O-])O.[K+].[K+].[K+]
9005-64-5500-018-3JRC-000113Tween 20-
97-74-5202-605-7JRC-000128Tetramethylthiuram MonosulphideCN(C)C(=S)SC(=S)N(C)C

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